From Wikipedia: "More recently, its leading practitioners include Evgeny Bareev, Alexey Dreev, Mikhail Gurevich, Alexander Khalifman, Smbat Lputian, Alexander Morozevich, Teimour Radjabov, Nigel Short, Gata Kamsky, and Yury Shulman."
I've never seen its lack of top-level players' usage as a reason not to play it though :) Go MacCutcheon!
@josevitor91 Against the Advance, I play 3... c5 and normally get the kind of game I want looking for the usual cxd4 or going for f6. Nimzowitch played the advance a lot (Advance is actually also known as the Nimzowitsch variation) so maybe look at his games and look at what he did...
If you mean White's third move, I prefer Nc3. If they go for the Classical I try the Alekhine-Chatard gambit (e4 e6 d4 d5 Nc3 Nf6 Bg5 Be7 e5 Nfd7 h4) but normally they just play c5 and dont take the bishop....
Of course, you can play normally. f4, Nf3, Bd3 and the like. After taking on e7 of course.
Or if they play the Burn variation (well, I guess that might be a variation in the Classical? So by the Classical I mean with Be7...) it may continue 4... dxe4 5. Nxe4 5 Be7 6 Bxf6 Bxf6 7. Nf3 Nd7 or 7... 0-0.
I remember Morozevich tried 5... Be7 6 Bxf6 gxf6 didn't he? Playing f5 and the like. And Bf6.
There's the Rubinstein with 3... dxe4 but I personally don't like that line. White should be better, but it is drawish.
Then you have the Winawer. Options include played a3 and expect Bxc3+ bxc3. You can enter the crazy lines with Qg4 but do so at your own peril....
Also, you cam just play e5. I remember this as the Lajos Steiner variation. Black will often then just play the 'normal' French way with moves like c5.
The MacCutcheon is my personal favourite. It follows the Classical up to Bg5 and the Black plays Bb4!? I normally like the lines with Kf8 (yes, you read that right. The king normally runs to c7 later though) as I feel black has sufficient defensive resources on the kingside and has good play on the Q-side. But not all lines allow Kf8, like e x Nf6. But still, lot of room there too.
You also have the Tarrasch with Nd2, the idea being to play c3 later. Thats fine, but I dont believe it troubles back over-much either. It's less aggressive but white hopes to consolidate a small advantage.
Just don't play the exchange....
Don't get overly aggressive if you're playing white. Black has opted for a closed game and it can be hard to blow it up, if not impossible. Maneuver, improve your position. Maybe black will be overly aggressive :)